You are hereFeed aggregator / Nature Chemical Biology
Nature Chemical Biology
A practical philosophy
Tue, 07/20/2010 - 02:00A practical philosophy
Nature Chemical Biology 6, 559 (2010). doi:10.1038/nchembio.417
The expanding biotechnology landscape offers new intersections with traditional strengths in chemical biology.
Categories: Journals
The chemical biology of synapses and neuronal circuits
Tue, 07/20/2010 - 02:00The chemical biology of synapses and neuronal circuits
Nature Chemical Biology 6, 560 (2010). doi:10.1038/nchembio.408
Author: Haruhiko Bito
Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have important biological consequences. Powerful chemical biological techniques have now been developed to decipher the dynamic stability of the synapses and to further interrogate the complex properties of neuronal circuits.
Categories: Journals
Our choices from the recent literature
Tue, 07/20/2010 - 02:00Our choices from the recent literature
Nature Chemical Biology 6, 564 (2010). doi:10.1038/nchembio.415
Categories: Journals
Stapled peptides: Magic bullets in nature's arsenal
Tue, 07/20/2010 - 02:00Stapled peptides: Magic bullets in nature's arsenal
Nature Chemical Biology 6, 566 (2010). doi:10.1038/nchembio.407
Author: Joshua A Kritzer
Selectivity is a key obstacle in drug development. A new study describes how “peptide stapling,” a technique for making peptide α-helices more potent and cell permeable, allows the design of MCL-1 inhibitors with extraordinary selectivity.
Categories: Journals
Non-covalent interactions: Fold globally, bond locally
Tue, 07/20/2010 - 02:00Non-covalent interactions: Fold globally, bond locally
Nature Chemical Biology 6, 567 (2010). doi:10.1038/nchembio.413
Author: Neal J Zondlo
Protein structures are considerably stabilized by local interactions. A new computational and structural analysis discovers that n→π* interactions between consecutive residues are stabilizing and ubiquitous in a variety of secondary structures.
Categories: Journals
Bioinorganic chemistry: Getting a grip on iron
Tue, 07/20/2010 - 02:00Bioinorganic chemistry: Getting a grip on iron
Nature Chemical Biology 6, 568 (2010). doi:10.1038/nchembio.411
Author: Caroline Philpott
Siderocalin (also known as lipocalin 2) is a component of the innate immune system that binds and sequesters bacterial iron compounds in the blood and urine. A new study identifies iron–catechol complexes as endogenous ligands for siderocalin, which can deliver the iron compounds to the kidney.
Categories: Journals
Microscopy: GPCR dimers moving closer
Tue, 07/20/2010 - 02:00Microscopy: GPCR dimers moving closer
Nature Chemical Biology 6, 570 (2010). doi:10.1038/nchembio.409
Authors: Manuela Ambrosio & Martin J Lohse
Time-resolved fluorescence resonance energy transfer (TR-FRET) measurements with selective, fluorescently labeled ligands support the existence of GPCR dimers in native tissues and suggest that activated GPCR dimers are asymmetric.
Categories: Journals
Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis
Tue, 07/20/2010 - 02:00Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis
Nature Chemical Biology 6, 630 (2010). doi:10.1038/nchembio0810-630a
Author: Derrick Sek Tong Ong, Ting-Wei Mu, Amy E Palmer & Jeffery W Kelly
Categories: Journals
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
Tue, 07/20/2010 - 02:00Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
Nature Chemical Biology 6, 630 (2010). doi:10.1038/nchembio0810-630b
Author: Yao-Wen Wu, Lena K Oesterlin, Kui-Thong Tan, Herbert Waldmann, Kirill Alexandrov & Roger S Goody
Categories: Journals
ABC proteins in antigen translocation and viral inhibition
Sun, 07/18/2010 - 23:00ABC proteins in antigen translocation and viral inhibition
Nature Chemical Biology 6, 572 (2010). doi:10.1038/nchembio.410
Authors: David Parcej & Robert Tampé
Categories: Journals
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
Sat, 07/10/2010 - 23:00Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
Nature Chemical Biology 6, 587 (2010). doi:10.1038/nchembio.396
Authors: Laura Albizu, Martin Cottet, Michaela Kralikova, Stoytcho Stoev, René Seyer, Isabelle Brabet, Thomas Roux, Hervé Bazin, Emmanuel Bourrier, Laurent Lamarque, Christophe Breton, Marie-Laure Rives, Amy Newman, Jonathan Javitch, Eric Trinquet, Maurice Manning, Jean-Philippe Pin, Bernard Mouillac & Thierry Durroux
Categories: Journals
n→π* interactions in proteins
Sat, 07/10/2010 - 23:00n→π* interactions in proteins
Nature Chemical Biology 6, 615 (2010). doi:10.1038/nchembio.406
Authors: Gail J Bartlett, Amit Choudhary, Ronald T Raines & Derek N Woolfson
Categories: Journals
Palmitoylome profiling reveals S-palmitoylation–dependent antiviral activity of IFITM3
Sat, 07/03/2010 - 23:00Palmitoylome profiling reveals S-palmitoylation–dependent antiviral activity of IFITM3
Nature Chemical Biology 6, 610 (2010). doi:10.1038/nchembio.405
Authors: Jacob S Yount, Bruno Moltedo, Yu-Ying Yang, Guillaume Charron, Thomas M Moran, Carolina B López & Howard C Hang
Categories: Journals
Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex
Sat, 06/26/2010 - 23:00Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex
Nature Chemical Biology 6, 602 (2010). doi:10.1038/nchembio.402
Authors: Guanhu Bao, Matthew Clifton, Trisha M Hoette, Kiyoshi Mori, Shi-Xian Deng, Andong Qiu, Melanie Viltard, David Williams, Neal Paragas, Thomas Leete, Ritwij Kulkarni, Xiangpo Li, Belinda Lee, Avtandil Kalandadze, Adam J Ratner, Juan Carlos Pizarro, Kai M Schmidt-Ott, Donald W Landry, Kenneth N Raymond, Roland K Strong & Jonathan Barasch
Categories: Journals
Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini
Sat, 06/26/2010 - 23:00Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini
Nature Chemical Biology 6, 621 (2010). doi:10.1038/nchembio.400
Authors: Xuan Yue, Jacob C Schwartz, Yongjun Chu, Scott T Younger, Keith T Gagnon, Sayda Elbashir, Bethany A Janowski & David R Corey
Categories: Journals
An ATP-independent strategy for amide bond formation in antibiotic biosynthesis
Sat, 06/19/2010 - 23:00An ATP-independent strategy for amide bond formation in antibiotic biosynthesis
Nature Chemical Biology 6, 581 (2010). doi:10.1038/nchembio.393
Authors: Masanori Funabashi, Zhaoyong Yang, Koichi Nonaka, Masahiko Hosobuchi, Yoko Fujita, Tomoyuki Shibata, Xiuling Chi & Steven G Van Lanen
Categories: Journals
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
Sat, 06/19/2010 - 23:00The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
Nature Chemical Biology 6, 595 (2010). doi:10.1038/nchembio.391
Authors: Michelle L Stewart, Emiko Fire, Amy E Keating & Loren D Walensky
Categories: Journals
Unlocking the lipid labyrinth
Fri, 06/18/2010 - 02:00Unlocking the lipid labyrinth
Nature Chemical Biology 6, 471 (2010). doi:10.1038/nchembio.404
Progress in understanding the functions of individual lipids has lagged behind that for other bioactive molecules, but recent technologies that enable the monitoring of individual lipids provide hope.
Categories: Journals
Challenges in studying phospholipid signaling
Fri, 06/18/2010 - 02:00Challenges in studying phospholipid signaling
Nature Chemical Biology 6, 473 (2010). doi:10.1038/nchembio.389
Author: Carsten Schultz
Because of the large number of phospholipids, their highly active metabolism and our lack of understanding of protein-lipid specificity, lipid signaling is a particularly challenging subject to study. Help might come from new tools that will allow us to follow and manipulate lipids and lipid-binding proteins in living cells.
Categories: Journals
Seeing the future of bioactive lipid drug targets
Fri, 06/18/2010 - 02:00Seeing the future of bioactive lipid drug targets
Nature Chemical Biology 6, 476 (2010). doi:10.1038/nchembio.394
Authors: Jilly F Evans & John H Hutchinson
Bioactive lipid signaling allows individual cells within the body to 'see' the surrounding environment and to respond in ways that will benefit the whole organism. Successful drug development for bioactive lipid targets requires a deep knowledge of the biology and pathobiology of each specific lipid signaling pathway.
Categories: Journals