Chemistry & Biology

In This Issue

Finger Pointing: Engineered Zinc-Finger Proteins Allow Precise Modification and Regulation of Genes

Chandra Shekhar.

Tracing the Silhouette of Individual Cells in S/G2/M Phases with Fluorescence

Asako Sakaue-Sawano, Kenji Ohtawa, Hiroshi Hama, Masako Kawano, Masaharu Ogawa, Atsushi Miyawaki.

Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB

Emma M.V. Johansson, Shanika A. Crusz, Elena Kolomiets, Lieven Buts, Rameshwar U. Kadam, Martina Cacciarini, Kai-Malte Bartels, Stephen P. Diggle, Miguel Cámara, Paul Williams, Remy Loris, Cristina Nativi, Frank Rosenau, Karl-Erich Jaeger, Tamis Darbre, Jean-Louis Reymond.

Supramolecular Iron Cylinder with Unprecedented DNA Binding Is a Potent Cytostatic and Apoptotic Agent without Exhibiting Genotoxicity

Anna C.G. Hotze, Nikolas J. Hodges, Rachel E. Hayden, Carlos Sanchez-Cano, Christopher Paines, Natalia Male, Man-Kit Tse, Chris M. Bunce, J. Kevin Chipman, Michael J. Hannon.

In Vitro Reconstituted Biotransformation of 4-Fluorothreonine from Fluoride Ion: Application of the Fluorinase

Hai Deng, Stuart M. Cross, Ryan P. McGlinchey, John T.G. Hamilton, David O'Hagan.

Directed Evolution of a Lysosomal Enzyme with Enhanced Activity at Neutral pH by Mammalian Cell-Surface Display

Kai-Chuan Chen, Chia-Hung Wu, Chuan-Yuan Chang, Wei-Cheng Lu, Qingzong Tseng, Zeljko M. Prijovich, Wolfgang Schechinger, Yen-Chywan Liaw, Yu-Lin Leu, Steve R. Roffler.

Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE

Chand Singh Mangat, Eric David Brown.

Targeting a Uniquely Nonspecific Prenyl Synthase with Bisphosphonates to Combat Cryptosporidiosis

Jennifer D. Artz, James E. Dunford, Michael J. Arrowood, Aiping Dong, Maksymilian Chruszcz, Kathryn L. Kavanagh, Wladek Minor, R. Graham G. Russell, F. Hal Ebetino, Udo Oppermann, Raymond Hui.

Nitrosothiol Reactivity Profiling Identifies S-Nitrosylated Proteins with Unexpected Stability

Jeremy S. Paige, Guoqiang Xu, Branka Stancevic, Samie R. Jaffrey.

The Importance of Odorant Conformation to the Binding and Activation of a Representative Olfactory Receptor

Zita Peterlin, Yadi Li, Guangxing Sun, Rohan Shah, Stuart Firestein, Kevin Ryan.

Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii

Shuhao Wang, Yuquan Xu, Erin A. Maine, E.M. Kithsiri Wijeratne, Patricia Espinosa-Artiles, A.A. Leslie Gunatilaka, István Molnár.

In This Issue

Food and Drugs: Arena Pharmaceuticals Develops Next Generation Obesity Drug

Wendy Wolfson.

N-Acylhomoserine Lactone-Mediated Quorum Sensing: A Twist in the Tail and a Blow for Host Immunity

Margaret Cooley, Siri Ram Chhabra, Paul Williams.

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Ariele Viacava Follis, Dalia I. Hammoudeh, Huabo Wang, Edward V. Prochownik, Steven J. Metallo.

Proposed Arrangement of Proteins Forming a Bacterial Type II Polyketide Synthase

Gaetano Castaldo, Jurica Zucko, Sibylle Heidelberger, Dušica Vujaklija, Daslav Hranueli, John Cullum, Pakorn Wattana-Amorn, Matthew P. Crump, John Crosby, Paul F. Long.

Expression of Histone H3 Tails with Combinatorial Lysine Modifications under the Reprogrammed Genetic Code for the Investigation on Epigenetic Markers

Taek Jin Kang, Satoshi Yuzawa, Hiroaki Suga.

In Vivo and In Vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont

Nicole B. Lopanik, Jennifer A. Shields, Tonia J. Buchholz, Christopher M. Rath, Joanne Hothersall, Margo G. Haygood, Kristina Håkansson, Christopher M. Thomas, David H. Sherman.

Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode Nɛ-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification

Tatsuo Yanagisawa, Ryohei Ishii, Ryuya Fukunaga, Takatsugu Kobayashi, Kensaku Sakamoto, Shigeyuki Yokoyama.